| Cytokeratin Immunohistochemistry of Acquired Cholesteatoma in Middle Ear |
| Keehyun Park, MD1, Young-Myoung Chun, MD1, and Hong-Joon Park, MD2 |
| 1;Department of Otolaryngology, College of Medicine, Yonsei University, Seoul, 2;Department of Otolaryngology, College of Medicine, Ajou University, Seoul, Korea |
| 중이진주종상피의 사이토케라틴에 대한 면역조직화학적 연구 |
| 박기현1 · 전영명1 · 박홍준2 |
| 연세대학교 의과대학 이비인후과학교실1;아주대학교 의과대학 이비인후과학교실2; |
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| ABSTRACT |
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Cholesteatoma matrix, ear canal skin, postauricular skin, and middle ear mucosa were taken during middle ear surgery, and immunohistochemical technique was used to localize cytokeratin patterns of these tissues. In this study, we investigated differentiation of 4 different epitheliums using 5 monoclonal anti-epithelial keratin antibodies(AE) : AE-1, AE-2, AE-3, AE-5, AE-8. Several differences of cytokeratin patterns were observed between cholesteatoma matrix and postauricular skin as well as between cholesteatoma and middle ear mucosa. However, similarity of cytokeratin patterns was observed between cholesteatoma matrix and ear canal skin. These findings support the skin type epithelial origin of cholesteatoma matrix and strongly favor the immigration theory in the pathogenesis of cholesteatoma.
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| Keywords:
Aquired cholesteatomaㆍCytokeratinㆍImmunohistochemistry. |
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