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Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1990;33(2): 361-7. |
Protective Effect of Chlorpromazine from Ischemic and Reoxygenation Injuries on Rat Heart |
Myeong Soo Jang, MD1, Kei Won Song, MD1, Jang Su Suh, MD1, Seok Keun Yoon, MD1, Mun Heum Park, MD1, Oh Cheol Kwon, MD2, and Kwang Youn Lee, MD2 |
1;Department of Otorhinolaryngology, 2;Pharmacology, Yeungnam University, College of Medicine, Korea |
Chlorpromazine의 심허혈 손상방지 효과 |
장명수1 · 송계원1 · 서장수1 · 윤석근1 · 박문흠1 · 권오철2 · 이광윤2 |
영남대학교 의과대학 이비인후과학교실1;약리학교실2; |
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ABSTRACT |
Ischemia causes a depression in myocardial activity and a deterioration in calcium homeostasis. This study was designed to investigate the protective effect of chlorpromazine, an inhibitor of phospholipase, on myocardial cells from ischemia or reoxygenation injury. Isolated hearts from Sprague-Dawley rats(200~230g BW) were suspended on the Langendorff's heart preparation apparatus. The myocardial activity was measured by means of left ventricular pressure(LVP), myocardial contractility(dp/dt) and heart rate(HR). Chlorpromazine 500ng/L did not affect the reduction of myocardial activity during global ischemia. In the period of reoxygenation, chlorpromazine, by the same concentration, strikingly increased the recovery of LVP and dp/dt while it did not affect the recovery of HR. These results suggest that chlorpromazine protects the myocardium from the reoxygenation injury.
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