Yong Seong Shin, MD, Ju Hyung Kim, MD, Kyung Rae Kim, MD, Chul Won Park, MD, Hyung Seok Lee, MD, and Kyung Sung Ahn, MD |
Malignant tumors of the nasopharynx account for about 2% of the head and neck malignancies and the incidence is different from geography and races, especially high in Chinese. Not only due to late appearing symptoms but also due to anatomical complexity of the nasopharynx and difficulties in treatment, radiation therapy seems to be the most useful treatment method. In these days, surgical treatment for nasopharyngeal malignancies is being attempted with increasing tendency of the skull base surgery but the follow-up studies are not done, so the results are not known yet. We report the results of an analysis about 27 patients diagnosed as nasopharyngeal malignant tumors and treated with radiation therapy in Han Yang University Hospital from June, 1983 to May, 1985. The rusults were as following ; 1) Among 27 cases, 13 cases were male and 14 cases were female, so that no significant difference was noted between sex and the mean age was 50.1 years old, and the highest incidences of age distribution were the 5th. and 7th. decades(22.2%). 2) Presenting symptoms and signs were neck mass in 23 cases(85.2%), nasal symptom in 14 cases(51.9%), ear symptom in 12 cases(44.4%), headache in 5 cases(33.3%), throat symptom in 5 cases(33.3%), neurological symptom in 4 cases(14.8%) and respiratory symptom in 3 cases(11.1%). 3) Duration of onset was from 2 weeks to 12 months and average 4.9 months. 4) Histopathological findings were squamous cell carcinoma in 19 cases(70.4%), malignant lymphoma in 4 cases(14.8%), undifferentiated carcinoma in 2 cases(7.4%) and mucoepidermod and adenocystic carcinoma in each 1 case(3.7%). 5) The clinical staging was based on the physical examination, C-T scanning and the TNM system of AJCC, and there were 12 cases(44.5%) of stage IV, 11 cases(40.7%) of stage III and 4 cases(14.8%) of stage I. 6) Radiation dosage was 5,000-7,000 rads on the nasopharyngeal area and when neck mass was present, another 2,000-5,000 rads on the lateral cervical area. 7) Treatment results after 3 years follow-up are alive with no evidence of disease in 9 cases(33.3%), alive with local recurrence, lymph node invasion and cranial nerve extension in 3 cases(11.1%), and they were treated with radical neck dissection and chemotherapy. 9 cases(33.3%) died due to distant metastasis and 2 cases(7.4%) were unable to follow-up after full course of radiation therapy, and 4 cases(14.8%) refused the treatment during radiation therapy.
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