Nasopharyngeal cancer has manifested many symptoms and signs due to the anatomical characteristics. Therefore, early diagnosis of the nasopharyngeal cancer is difficult. This malignant tumor is not common than that of the other site, and shows quite a different incidence according to the geographical area and the race. It was also reported to occur in the family. Recently authors had experienced a case of nasopharyngeal cancer in sibling. We report this case with review of the literature.